Whole-body Autoradiography of Bumetanide-14C in Dogs by Round Saw Method
نویسندگان
چکیده
منابع مشابه
Distribution of [2-14C]merbarone in mice by autoradiography of whole-body cryosections.
The distribution of radiolabel in male mice was studied by autoradiography of whole-body cryosections at intervals during 24 h after i.v. injection (46.6 mg/kg) and during 4 h after oral administration (140 mg/kg) of [2-14C]merbarone. Following injection, radioactivity levels in the blood and highly vascular tissues declined to 8 h at which time only low levels were present in the systemic circ...
متن کاملIntraduodenally administered 14C-urokinase in Macaca Irus revealed by autoradiography.
Intraduodenally administered 14C-urokinase (14C-UK) was located in Macaca Irus by autoradiography. Sagittal sections, approximately 40 micron thick, of a frozen monkey were applied against X-ray films. Autoradiograms thus obtained indicated that a part of intraduodenally administered 14C-UK was incorporated into the systemic blood circulation by transintestinal mucosal membrane.
متن کاملThe utilisation of Quantitative Whole Body Autoradiography (QWBA) methods to investigate whole body tissue distribution in the minipig
The choice of the correct species for toxicity testing of drug candidates being developed for human use is a critical one. Rodents are the commonly used 1 species and monkeys, pigs and dogs are the candidates available for the 2 species. These all have sufficient background data to be used in toxicology studies but the choice has to be made which is most appropriate and representative of the cl...
متن کاملEffect of hydrofluoric acid on glucose metabolism of the mouse studied by whole-body autoradiography.
Distribution of radioactive carbon from [U-14C]glucose in the mouse poisoned by hydrofluoric acid has been studied by whole-body autoradiography. Under normal conditions, the highest autoradiographic density was found in the Harder's gland, palatine gland, sublingual gland, large intestinal mucosa, and many regions of the central nervous system 30 minutes after intraperitoneal injection of [U-1...
متن کاملEvaluation of whole-body vibration by the category judgment method.
The purpose of this research is to establish a scale for comfort with regard to whole-body vibration by the category judgment method. Experiments were conducted with random signals as stimuli. These stimuli consisted of three types of signal, namely stimulus F, with flat PSD (Power Spectrum Density) ranging from 1 to 100 Hz, stimulus H with PSD, which became 20 dB higher at 100 Hz than at 1 Hz,...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: RADIOISOTOPES
سال: 1979
ISSN: 1884-4111,0033-8303
DOI: 10.3769/radioisotopes.28.12_745